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KMID : 1098420080160050341
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 5 p.341 ~ p.348
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Screening for Human ACAT-1 and ACAT-2 Inhibitory Activity of Edible Plant Extracts
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Lee Dae-Young
Jeong Tae-Sook
Lyu Ha-Na
Bang Myun-Ho
Hong Yoon-Hee
Lee Youn-Hyung
Baek Nam-In
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Abstract
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Cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Inhibitory effects on ACAT of the MeOH extracts prepared from 163 edible plants were evaluated. 15 species out of 163 species exhibited higher than 50% of inhibition on the hACAT-1 and 9 species exhibited higher than 50% of inhibition on the hACAT-2 activity at their concentration of .
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KEYWORD
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Edible Plant, Acyl-CoA: Cholesterol Acyltransferase (ACAT), Hypercholesterolemia, Atherosclerosis
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